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1、Severeacuterespiratorysyndrome-coronavirusandhumancoronavirus-NL63:anupdatedoverviewaa,bVanessaDittandOliverSchildgenSevereacuterespiratorysyndrome-coronavirusandhumancoronavirus-NL63,thoughbothbelongingtodifferentgroupsofthesamegenus,areinterestingrepresentativesoftheirkind;
2、the?rstoneisofzoonoticorigin,accountedforthepandemicin2002/2003thatwasdistributedworldwideandhadamortalityrateofabout10%,theotheronewasidenti?edlaterandprobablyhasbeencirculatingwithinthepopulationforcenturiesandbelongstothosevirusesthatcausethe‘commoncold’.Alotofefforthasbee
3、nmadetoinvestigatebothvirusesandtounderstandtheirdifferencesandtheirsimilaritieswithregardtofurtherzoonoticevents.Thisreviewgivesanoverviewofsevereacuterespiratorysyndrome-coronavirusandhumancoronavirus-NL63,theirhistoryandthecurrentstateofresearch.?2009WoltersKluwerHealth
4、Li
5、ppincottWilliams&WilkinsReviewsinMedicalMicrobiology2009,20:19–28Keywords:coronaviruses,NL63,severeacuterespiratorysyndromeIntroductionandsimilaritiesandtheircharacteristics.ThisreviewwillmainlyfocusonSARS-CoVandHCoV-NL63.Sincethe?rsthumanpathogeniccoronaviruses(HCoV)-229Eand
6、HCoV-OC43wereidenti?edinthe1960sandassociatedwithmildrespiratorydiseases[1,2],onlylittlenewinformationhademergedinthis?elduntilthebeginningofthiscentury.SuddenlythefocuswasIdenti?cationofsevereacuterespiratorydirectedtowardscoronavirusesagainasaspecial,mean-syndrome-coronavir
7、usandhumanwhilewellknownmemberofthisgroupappearedincoronavirus-NL632002/2003[3–5]intheprovinceofGuangDong(China)andcaused‘severeacuterespiratorysyndrome(SARS)’;Severaltechniqueswereemployedtocharacterizeandfatalsymptomsthatwereveryunusualforcoronavirusesidentifythecausativeag
8、entofSARS.Patientmaterialwasastheywereconsideredtobenonhazardousatthistime.inoculatedontorhesusmonkeykidneycells(fRhk4)toStrenuouseffortsweremadetoidentifyandcharacterizeobserveforcytopathiceffects;testsforotherknownthisnewpandemicthreatandtocurbit.respiratoryviruseswerenegat
9、ive.Electronmicroscopyrevealedthemorphologyandledtocharacterizationo
