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1、HematopoieticStemCellTransplantation周紅升,PhD,MDDepartmentofHematologyNanfangHospitalQ&ABMTisaSurgery?WhatkindofptsneedBMT?AIDS?HowBMTcureleukemia?Post-BMTneedimmuosuppression?WhatisGVHD&GVL?Howtofindamatchingdonor?CostofBMT?WhatcanUdo?OutlineoftheSlidesBackgroundofstemcell&HSCTDefinit
2、ion&Classification&EligibilityStepbystepofProcedureAcuteChronicComplicationsofHSCTKeywordsStemcell,HematopoieticstemcellMHC,HLAHSCT,PBSCT,CBT,BMT,NST,RISTGVHD,aGVHD,cGVHD,GVL,GVTOSEFSTRMQoLStemcellageneralizedmothercellthathaspluripotencydescendantsmayspecializeindifferentdirectionsH
3、ematopoeiticStemcellpluripotentstemcellsthatgiverisetoallthebloodcelltypesincludingmyeloid(monocytesandmacrophages,neutrophils,basophils,eosinophils,erythrocytes,megakaryocytes/platelets,dendriticcells),andlymphoidlineages(T-cells,B-cells,NK-cells).HLAHumanleukocyteantigenakeypartoft
4、hehumanimmunesystemMHCMajorhistocompatibilitycomplexahighlypolymorphicregiononchromosome6withgenesparticularlyinvolvedinimmunefunctionsMHCHLAengraftment-relatedHSCTHematopoieticstemcelltransplantationPBSCTPeripheralbloodstemcelltransplantationCBTCorebloodtransplantationBMTBonemarrowt
5、ransplantationNSTNon-myeloblativeStemcellTransplantationRISTReducedIntensifyingStemcellTransplantationGVHDGraft-Versus-HostDiseaseaGVHDacuteGVHDcGVHDchronicGVHDGVLGraft-Versus-LeukemiaGVTGraft-Versus-TumorDLIDonorLymphocyteInfusionTRMTransplantation-RelatedMorbidityQoLQualityofLifePa
6、rt1Background StemCellSMART:UniqueFeatureofHSCTCheng.‘SMART’stemcells,GeneTherapy2008;15,67–73Self-renewalofSMARTstemcellSelf-renewal---asymmetrical:1daughterSC&1differentiatedcellafterdivision---symmetrical,2daughterSCafterdivision---HSCs,asymmetricalself-renewingdivisionSelf-renewa
7、lofSMARTStemcellhttp://www.moragabiotech.com/techblscs.htmBlastomere-LikeStemCellsMatureofSMARTstemcellDifferentiationisthemostdirectcellularbasisforusingstemcellsinregenerativemedicine.Allstemcellsareabletodifferentiateintospecifiedcelltypesunderspecificconditions.MatureofStemCellAp
8、optosisofSMA
