資源描述：
《Colors with Functions Elucidating the Biochemical and Molecular Basis of Carotenoid Metabolism》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫。
1、NU30CH03-vonLintigARI7July20102:40ColorswithFunctions:ElucidatingtheBiochemicalandMolecularBasisofCarotenoidMetabolismJohannesvonLintigDepartmentofPharmacology,SchoolofMedicine,CaseWesternReserveUniversity,Cleveland,Ohio44106-4965;email:jxv99@case.eduAnnu.Rev.Nu
2、tr.2010.30:35–56KeyWordsFirstpublishedonlineasaReviewinAdvanceoncarotenoid-oxygenases,retinoids,nuclearreceptors,vision,lipidApril20,2010transport,lipidmetabolismTheAnnualReviewofNutritionisonlineatnutr.annualreviews.orgAbstractThisarticle’sdoi:Carotenoidsaffect
3、arichvarietyofphysiologicalfunctionsinnatureand10.1146/annurev-nutr-080508-141027arebene?cialforhumanhealth,servingasantioxidantsinlipophilicen-byKunmingInstituteofZoologyon04/30/11.Forpersonaluseonly.Annu.Rev.Nutr.2010.30:35-56.Downloadedfromwww.annualreviews.o
4、rgCopyrightc2010byAnnualReviews.vironmentsandbluelight?ltersinthemaculaofhumanretina.TheseAllrightsreserveddietarycompoundsalsoserveasprecursorsofauniquesetofapo-0199-9885/10/0821-0035$20.00carotenoidcleavageproducts,includingretinoids.Althoughknowledgeaboutret
5、inoidbiologyhastremendouslyincreased,themetabolismofretinoids’parentprecursorsremainspoorlyunderstood.Recently,molecularplayersincarotenoidmetabolismhavebeenidenti?edandbiochemicallycharacterized.Moreover,mutationsintheircorrespond-inggenesimpaircarotenoidmetabo
6、lismandinducevariouspathologiesinanimalmodels.Polymorphismsinthesegenesaltercarotenoidandretinoidhomeostasisinhumansaswell.Thisreviewsummarizesourcurrentknowledgeaboutthemolecular/biochemicalbasisofcarotenoidmetabolismandparticularlythephysiologicalroleofcaroten
7、oidsinretinoid-dependentphysiologicalprocesses.35NU30CH03-vonLintigARI7July20102:40considerableamountsofcarotenoids.Physio-ContentslogicalfunctionsattributedtothesecompoundsareassociatedwiththeircapabilitytoactasINTRODUCTION..................36antioxidants,e.g.,
8、asfreeradicalscavengers,DROSOPHILAMELANOGASTERinlipophilicenvironmentssuchasmembranesISANEXCELLENTMODELandlipoproteins(forreview,see23).Addi-TOSTUDYCAROTENOIDtionally
