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1、VeterinaryMicrobiology,31(1992)1-101ElsevierSciencePublishersB.V.,AmsterdamCoronavirusinfectioninmink(Mustelavison).SerologicalevidenceofinfectionwithacoronavirusrelatedtotransmissiblegastroenteritisvirusandporcineepidemicdiarrheavirusP.Havea,V.Movinga,V.Svanssonb,,~.Uttenthalc,B.BlochbaS
2、tateVeterinaryInstituteforVirusResearch,Lindholm,DK-4771Kalvehave,DenmarkbDepartmentofVeterinaryMicrobiology,RoyalVeterinaryandAgriculturalUniversity,DK-1870FrederiksbergC.,DenmarkCDanishFurbreedersAssociation,DK-2600Glostrup,Denmark(Accepted18September1991)ABSTRACTHave,P.,Moving,V.,Svans
3、son,V.,Uttenthal,A.andBloch,B.,1992.Coronavirusinfectioninmink(Mustelavison).Serologicalevidenceofinfectionwithacoronavirusrelatedtotransmissiblegas-troenteritisvirusandporcineepidemicdiarrheavirus.Vet.Microbiol.,31:1-10.Antibodiestoatransmissiblegastroenteritisvirus(TGEV)-relatedcoronavi
4、rushavebeendem-onstratedinminkserabyindirectimmunofluorescence,peroxidase-linkedantibodyassaysandim-munoblotting.Thisisthefirstserologicalevidenceofaspecificcoronavirusinfectioninmink.Theputativeminkcoronavirus(MCV)seemstobewidespreadintheDanishminkpopulationwithaprevalenceapproaching100%
5、.AnalysisbyimmunoblottinghasshownthatMCViscloselyrelatedtoTGEVbythespike(S),matrix(M)andnucleoprotein(N)polypeptides.Furthermore,antibodiestoMCValsocross-reactedwithNandMpolypeptidesofporcineepidemicdiarrheavirus(PEDV).ThusMCVmayoccupyanintermediatepositionbetweentheTGEVgroupofcoronavirus
6、esandPEDV.ThepossibilitythatMCVmaybeassociatedwithsyndromesofacuteenteritisinpreweaningminkisdiscussed.INTRODUCTIONCoronavirusesinfectanumberofmammalianandavianspeciesandthemammalianvirusesareusuallyplacedintwomajorserologicalgroupsrepre-sentedbymousehepatitisvirus(MHV)andtransmissiblegas
7、troenteritisvi-rus(TGEV)(SturmanandHolmes,1983,Siddelletal.,1983).TheMHVgroupincludesbovinecoronavirus(BCV),porcinehemagglutinatingen-cephalomyelitisvirus(HEV)andhumancoronavirus(HCV)OC-43.TheTGEVgroupincludesporcinerespiratorycoronavirus(PRCV)(Pensaertet0378-1135/9
