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1、AnnotationsCoronavirusesinBalkannephritisVirusesfoundinthekidneyswereforalongtimeconsideredtheantigenicdiversityofcoronaviruses,ofthelackofantigenstrivialsymbionts,aviralflora.Onlyrecentlyhasitbeenforstrainshavingfastidiousgrowthrequirements,andrecognizedthatthesevirusesmight
2、besubtlepathogens,becauseofthenecessitytoperformdifferentassayprocedurespossiblyinvolvedinslowinitiationofprogressiverenalfail-accordingtothevariousantigensused.Thecomplementure.’Electronmicroscopicstudieshaverevealedthepresencefixationreactionseemsratherunsuitableforserosurv
3、eys,ofvirus-likeparticlesinthekidneysofBalkannephritis(BN)sincecomplementfixingantibodiesarerelativelyshort-lived.patients:,1?suggestingtheimplicationofcoronavirusesinNeutralizationiseffectivebutexpensive,slowandtedious,renalpathology.’However,thepresenceofvirusesintissueswhi
4、lethehemagglutinationinhibitiontestisimpracticabledoesnotaloneestablishcausation8Theinvolvedviruscouldwithnon-hemagglutinatingcoronavirusstrains.Moreover,innotbeisolatedasyet,buteventhesuccessfulrecoveryofanachronicviralinfectionthereisalwaysthepossibilitythatagentfromthekidn
5、eyswouldprovideaveryloworderofantibodyproductionmaybemaskedbycompleteabsorptionevidenceforthepurposeofprovingcausality.@Inanearlierofcirculatingantibodybyexcessantigen.Ithastobepaper:wedescribedourprogramofworkonthepossibleviralrememberedthattheimmunofluorescencetestactuallye
6、tiologyofBNandpresentednegativeresultsonattemptsatdisclosedinthekidneysofBNpatientsagranularfluores-virusisolationandidentificationofantibodyreactivitytocencealongthebasementmembraneoftheglomeruli,6buttheselectedviralantigens.BecauseofthesuggestionthatBNinnatureofthedeposited
7、immunecomplexeshasnotbeenmanmightbecausedbyaslowporcinecoronavirusinfection,’investigated.thissecondprogressreportofourresultsisinorder.CoronavirusesareemergingasimportantcausesofcommonIntheabsenceofvirusisolations,emphasishasbeenplacedcold-likeillnessandareassumedtobeinvolve
8、dinnon-onseroepidemiologicalinvestigations.”Antibodieshavebeenbacter
