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1、VirusResearch,25(1992)213-22221301992ElsevierSciencePublishersB.V.Allrightsreserved016%1702/92/$05.00VIRUS00820ComparativeanalysesofthenucleocapsidgenesofseveralstrainsofinfectiousbronchitisvirusandothercoronavirusesAnnaK.Williams,LiWang,LoydW.SneedandEllenW.CollissonDepartmentofVet
2、erinaryPathobiology,CollegeofVeterinaryMedicine,TexasA&MUnicersity,CollegeStation,TX77843,USA(Received8April1992;revisionreceivedandaccepted4June1992)SummaryThenaturalsequencevariationsofthenucleocapsidgenesoftheGray,Arkansas99(Ark991,andHolland52(Ho11521strainsofinfectiousbronchiti
3、svirus(IBV)weredetermined.Thesewerecomparedwithpreviouslypublishedsequenc-ingdataofotherIBVstrains,aswellasothercoronaviruses,inordertocorrelatetheserologicalandevolutionaryrelationshipofcoronaviruses.IBVnucleotidesequencealignmentshowsthatoverallthesequencesarehighlyconserved,withh
4、omologiesfrom91.1to96.5%.However,therearealsotworegions(730to800and1138to1166)thatappeartobeevenmorehighlyconserved.Overall,thenucleocapsidproteinishighlyvariablebothinsizeandcompositionbetweencoronavirusmajorantigenicgroupsbutisconservedwithinthesegroups.Aphylogenetictreeofthenucle
5、ocapsidproteinofvariouscoronavirusesindicatesthatthecoronavirusesfallintodistinctgroupsthatcorrespondtothethreemajorantigenicgroups;however,aphylogenetictreeoftheIBVnucleocapsidshowsthatthisdoesnotholdtrueforthetypespecificantigenicgroupsofIBV.Nucleocapsidgene;Infectiousbronchitis;C
6、oronavirusAvianinfectiousbronchitisvirus(IBV)isahighlycontagiouspathogenofchickens.IBVinfectionischaracterizedbytrachealrales,coughingandsneezing,andcanalsocauselesionsinthereproductivetract,kidneys,andotherorgansCorrespondencetotE.W.Collisson,DepartmentofVeterinaryPathobiology,Coll
7、egeofVeterinaryMedicine,TexasA&MUniversity,CollegeStation,TX77843,USA.(Darbyshireetal.,1979).IBVwasthefirstcoronavirustobedescribed(SchalkandHawn,19311,andmanystrainsvaryingwidelyinvirulence,serotypeandpathotypehavebeenidentified(Cumming,1963;Darbyshireetal.,1979).Forexample,Beaudet
8、teisahighlyattenuat
