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1、ArchVirol(2000)145:2335–2349AntibodyresponsestorespiratorycoronavirusinfectionsofcattleduringshippingfeverpathogenesisX.Q.Lin1,K.L.O'Reilly1,J.Storz1,C.W.Purdy2,andR.W.Loan31DepartmentofVeterinaryMicrobiologyandParasitology,SchoolofVeterinaryMedicine,LouisianaS
2、tateUniversity,BatonRouge,LouisianaU.S.A.2ConservationandProductionResearchLaboratory,USDA,ARS,Bushland,Texas,U.S.A.3DepartmentofVeterinaryPathobiology,TexasA&MUniversity,CollegeStation,Texas,U.S.A.AcceptedMay11,2000Summary.Antibodyresponsesagainstrespiratorybo
3、vinecoronavirus(RBCV)infectionsweremonitoredincattlefromtheonsetofanaturallyoccurringsevereshippingfever(SF)epizootictocompleterecoveryofaffectedcattleorfatalout-comes.TheinfectionwithRBCVwasdetectedinnasalsecretionsof86cattle,and81ofthemdevelopedacuterespirato
4、rytractdisease,includingfatalpneumonia.CattlenasallysheddingRBCVatthebeginningoftheepizooticexperiencedchar-acteristicprimaryimmuneresponseswithspeci?cantibodiesforhemagglutinin-esterase(HE)andspike(S)glycoproteins.Virussheddinginnasalsecretionsofthemajorityoft
5、hecattleceasedbetweendays7and14withtheappearanceofHE-andS-speci?cantibodies.Nasalsamplesandlungtissuesfrom9ofthe10fatalcaseshadhightitersofRBCV,butthesecattlehadonlyIgMresponsestoRBCVinfections.CattleremainingnegativeinRBCVisolationtestsenteredthisepizooticwith
6、antibodiesagainstHEandS.Protectionagainstrespiratorytractdiseasewasapparentlyassociatedwithhighlevelofopsonicandvirus-neutralizingIgG2.TheHEandSglycoproteinswererecognizedearliestbythebovineim-munesystemwhiletheNproteininducedantibodyresponsesduringthelaterstag
7、eofinitialinfectionandtheearlystageofreinfection.Themembrane(M)glycoproteinwastheleastimmunogenicofthemajorviralstructuralproteins.IntroductionCoronaviruses,agenusinthefamilyCoronaviridae,areenveloped,positive-strandRNAvirusesthatemergeasincreasinglyimportantca
8、usesofhumanandanimaldiseases.Thesediseasesincluderespiratoryinfections,gastroenteritis,2336X.Q.Linetal.hepaticandneurologicaldisorders,immune-mediateddiseasesuchasfelinein-f
