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1、ResearchinVeterinaryScience/988,45,383-388AttemptedimmunisationofcatsagainstfelineinfectlousperitonitisusingcaninecoronavirusC.A.STODDART,J.E.BARLOUGH,C.A.BALDWIN"',F.W.SCOTT,CornellFelineHealthCenterandDepartmentofVeterinaryMicrobiology,ImmunologyandParasi
2、tology,SchurmanHall,NewYorkStateCollegeofVeterinaryMedicine,CornellUniversity,Ithaca,NewYork14853-6401,USASpecificpathogenfreekittenswerevaccinatedwithanperitonitis(FlP),characterisedbyfibrinousperitonitisunattenuatedfieldisolateofcaninecoronavirus(ccv)orpl
3、euritisandformationofdisseminatedpyo?eitherbyaerosolorsubcutaneously,andreceivedgranulomas.Currenttherapies,usuallyconsistingofboostingvaccinationsfourweekslater.Aerosolisa?corticosteroidsorothermorepotentcytoreductivetionelicitedahomologousvirus-neutralisi
4、ng(VN)drugs,areonlypalliativeinnatureandinmostantibodyresponsethatincreasedsteadilyoverafour?instancesareineffectiveathaltingtherelentlesslyweekperiodandlevelledoffonetotwoweeksafterprogressivecourseofthedisease.revaccination.Theinitialaerosoliseddoseproduc
5、edAsafeandeffectiveFIPvaccinehasnotyetbeenanasymptomaticinfectionwithexcretionofeevdeveloped.Experimentsthusfarreportedusingfromtheoropharynxuptoeightdaysaftervaccina?variousviruseswithintheFIPVantigenicclustertion;virussheddingwasnotdetected,however,after(
6、Pedersenetal1978)havenotbeensuccessfulinthesecondinoculation.Catsvaccinatedsub?conferringuniformlyprotectiveimmunity(TomaetcutaneouslydevelopedlowVNantibodytitresafteral1979,WoodsandPedersen1979,Pedersenetalthefirsteevdoseandexperiencedastrong1981,1984,Pede
7、rsenandBlack1983,Barloughetalanamnesticresponseaftertheseconddose.Neutralls?1984b,1985,Pedersenandfloyd1985).Para?ingantibodytitresthenlevelledoffonetotwoweeksdoxically,becauseoftheimmunopathologicalnatureafterrevaccinationatmeanvaluessomewhatlowerofthedise
8、ase,vaccinationwithsomefelinecorona?thanincatsvaccinatedbyaerosol.eevwasnotviruseshasactuallypredisposedcatstothedevelop?isolatedfromtheoropharynxaftereithersub?mentofFIPandproducedamorerapidandcutaneo
