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1、JournalofMedicalVirology9:209-216(1982)PrevalenceofHumanCoronavirusAntibodyinthePopulationofSouthernIraqHassanJ.HasonyandMalcolmR.MacnaughtonDivisionofCommunicableDiseases,ClinicalResearchCentre,Harrow,MiddlesexHA13UJ,EnglandSerafromadultsinSouthernIraqwerecollectedduringwinterandscreenedby
2、anenzyme-linkedimmunosorbentassayforthepresenceofantibodiestothetwoan-tigenicgroupsofhumancoronaviruses,the229EandtheOC43groups:91%oftheserahadantibodiestoatleastoneofthegroups,whereas4and5%oftheserahadantibodiestoonlythe229EorOC43groups,respectively.Therewassignifi-cantcorrelationbetweenth
3、elevelsofantibodytothe229EandOC43groupcoro-navirusesinthesesera.Keywords:HCVantibodies,2293andOC43groups,HCVinIraq,IraqiserumantibodiesINTRODUCTIONHumancoronaviruses(HCVs)areanimportantcauseofcommoncoldsinmanandupto25%ofcoldsmaybecausedbytheseviruses[BradburneandTyrrell,1971;Larsonetal,1980
4、;McIntosh,1974;Monto,19741.Recentreportshavesuggestedthatthesevirusesmaybeassociatedwithmoreseverediseases,andinparticulargastroen-teritis,butasyetthereisnoclearevidencetosupportthis[MacnaughtonandDavies,19811.SeveralreportshaveanalyzedtheextentofinfectionsinvariouspopulationsinAmericaandEu
5、ropebyestimatesofHCVantibodiesinserafrompatientsandvolun-teers[BradburneandSomerset,1972;Candeiasetal,1970;CavallaroandMonto,1970;HamreandBeem,1972;Hendleyetal,1972;Hovietal,1979;Kayeetal,1971;McIntoshetal,1970;Zakstelskayaetal,19721.Anumberofassayshavebeenused,in-cludingneutralization,comp
6、lementfixation,hemagglutinationinhibition,andradio-immunoassay.ThenumbersofsubjectswithsignificantHCVantibodyintheirseravariedconsiderablydependingonthepopulationstudied,timeofassay,assaysystemused,andmethodusedtodeterminesignificantlevelsofantibody.Inonereportmostoftheadultpopulationwasfou
7、ndtohaveserumantibodiestoHCVOC43asdetectedAcceptedforpublicationJanuary7,1982.AddressreprintrequeststoHassanJ.Hasony,DivisionofCommunicableDiseases,ClinicalResearchCentre,Harrow,MiddlesexHA13UJ,England.0146=6615/82/0903-0209$02.5001982AlanR.Liss,Inc.210H
