冠狀病毒Coronavirusl論文-1981 The pathogenesis of an enteric infection in pigs, experimentally induced by the coronavirus-like agent, CV 777.pdf

冠狀病毒Coronavirusl論文-1981 The pathogenesis of an enteric infection in pigs, experimentally induced by the coronavirus-like agent, CV 777.pdf

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1、VeterinaryMicrobiology,6(1981)157--165157ElsevierScientificPublishingCompany,Amsterdam--PrintedinTheNetherlandsTHEPATHOGENESISOFANENTERICINFECTIONINPIGS,EXPERI-MENTALLYINDUCEDBYTHECORONAVIRUS-LIKEAGENT,CV777P.DEBOUCK*,M.PENSAERT*andW.COUSSEMENT***LaboratoryofVirolog

2、yand**LaboratoryofPathology,FacultyofVeterinaryMedicine,StateUniversityofGent,Casinoplein24,B-9000Gent(Belgium)(Accepted16January1981)ABSTRACTDebouck,P.,Pensaert,M.andCoussement,W.,1981.Thepathogenesisofanentericinfectioninpigs,experimentallyinducedbythecoronavirus-

3、likeagent,CV777.Vet.Microbiol.,6:157--165.Sixteen2--3-days-oldcaesarean-derived,colostrum-deprivedpigletswereeachdosedoro-nasallywith2mlofabacteria-freefiltratecontaining104pig-infectious-dosesofCV777.Thepigletswerekilledatintervalsof12to120hafterinfection.Thecoro-n

4、avirus-likeagentcausedalocalinfectionoftheintestinaltractwhichresultedinvillousatrophy,malabsorptionanddiarrhea.Thepathogenesisofthisinfectionwassimilartothatoftransmissiblegastroenteritis(TGE),aknowncoronaviralinfectionofpigs.However,thereweresomedifferences.Byimmu

5、nofluorescentstaining,CV777antigenswerenotonlydetectedintheepithelialcellscoveringthesmallintestinalvilli,butalsointhecellsofthecolonicsurfaceepithelium.Occasionalfluorescencewasalsoseeninthesmallintestinalcryptepithelium,buttheregenerativecapacityofthecryptswasnota

6、ffected.TheprogressofintestinalepithelialcellinfectionbyCV777wasmuchslowerthanthatinTGE,resultinginalongerincubationperiodandinlessdrasticepithelialcelldestruction.TheinfectionofregeneratingcellsoccurredtoamuchhigherdegreeduringthelatestageofaCV777infectionthanhasbe

7、enobservedinTGE.INTRODUCTIONVirusescommonlyassociatedwithdiarrheainpigsaretransmissiblegastroenteritisvirus(TGEV),amemberoftheCoronaviridae,andtheporcinerotavirus.Thepathogenesisoftheintestinalinfectionduetothesevirusesiswelldocumented(HooperandHaelterman,1966,1969;

8、Pensaertetal.,1970a,b;Butleretal.,1974;PearsonandMcNulty,1977;Theftetal.,1978).Bothvirusesreplicateinthecytoplasmoftheabsorptiveepithelial

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