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1、J.Vet.Med.B35,435-442(1988)01988PaulPareyScientificPublishers,BerlinandHamburgISSN0931-1793FromAburahiLaboratories,ShionogiResearchLaboratories,ShionogiGCo.,Ltd.,Koka,Shiga520-34,JapanCharacterizationofLow-virulentMouseCoronavirusIsolatedfromFaecesinaMouseColonyT.HIRASAWA~,N.H
2、IRANO~,S.OHHARA~,K.MIKAZUKI~andY.HAYASHI!Addressofauthors:'AburahiLaboratories,ShionogiResearchLaboratories,Shionogi&Co.,Ltd.,Koka,Shiga520-34,and'DepartmentofVeterinaryMicrobiology,FacultyofAgriculture,IwateUniversity,Morioka-shi,Iwate020,JapanWith5figuresand2tables(Receivedf
3、orpublicationMarch9,1988)SummaryAviruswhichproducedcytopathiceffectwithsyncytiumformationwasisolatedfromthefaecesofapparentlyhealthymicebymousebraintumourcellculture,DBTcells.Theisolatewasvirologicallyandserologicallyidentifiedasmousecoronavirus.ItgrewwellinDBTcells,andformedc
4、learplaquesmuchsmallerinsizethanthoseofotherlow-virulentstrains.Inexperimentalinfections,theisolatecouldproduceonlyamildhepatitisincortisone-treatedweanlingmice.Fatalhepatitiswasnotobservedeveninmicetreatedwith10mgcortisone;whereasmanymicewerekilledbyotherlow-virulentstrains.K
5、eywords:Coronavirus,mouse,plaqueformation,experimentalinfectionIntroductionMousecoronavirus(murinehepatitisvirus;MHV),amemberofthefamilyCoronaviridae(23),isoneofthemostcommonpathogensoflaboratorymice.Thevirushasmanyantigenicallyrelatedstrainsorisolatesandcancausesignificantdis
6、easessuchasacutehepatitis,encephalomyelitis,infantdiarrhoeaandwastingsyndromeinathymicnudemice.However,MHVstrainsvarygreatlyintheirpathogenicity,andtheclinicalcourseoftheinfectiondependsonthevirusstrain,routeofinfectionandmanyhostfactors(1,2).Undernaturalconditions,MHVinfectio
7、nseemstobesubclinicalinmostcases.Thevirusishighlycontagiousandprobablytransmittedbyrespiratoryororo-faecalroutes(1,2,13,24).Concerningthelatterroute,entericinfectionofMHVstrains(4-6,9,18,22)andvirusexcretioninfaeces(13,22)havebeenreported.Recently,wehaveencounteredanMHVinfecti
8、onofpossiblelow-virulentstrain(20).Sincefaecesisoneofthesuita
